Academics

Elaborate Course:Molecular Biology

精品课程：分子生物学

  

I.Course Introduction (including teaching goals and requirements) within 300 words:

The students can grasp the basic knowledge of molecular biology, and are familiar with the principle of molecular biology technology; know development of it and application in medical.

II.Teaching Syllabus (including the content of chapters and sections. A sheet can be attached):

I Introduction 3h

1 A Brief History

2 The Molecular Nature of Genes

3 An Introduction to Gene Function

II Methods in Molecular Biology 3h

4 Molecular Cloning Methods

5 Molecular Tools for Studying Genes and Gene Activity

III Transcription in Prokaryotes 4h

6 The Transcription Apparatus of Prokaryotes

7 Operons: Fine Control of Prokaryotic Transcription

8 Major Shifts in Prokaryotic Transcription

9 DNA-Protein Interactions in Prokaryotes

IV Transcription in Eukaryotes 5h

10 Eukaryotic RNA Polymerases and their Promoters

11 General Transcription Factors in Eukaryotes

12 Transcription Activators in Eukaryotes

13 Chromatin Structure and Its Effects on Transcription

V Posttranscriptional Events 3h

14 Posttranscriptional Events I: Splicing

15 Posttranscriptional Events II: Capping and Polyadenylation

16 Posttranscriptional Events III: Other Events

VI Translation 3h

17 The Mechanism of Translation I: Initiation

18 The Mechanism of Translation II: Elongation and Termination

19 Ribosomes and Transfer RNA

VII DNA Replication, Recombination, and Transposition 6h

20 DNA Replication I: Basic Mechanism and Enzymology

21 DNA Replication II: Detailed Mechanism

22 Homologous Recombination

23 Site-Specific Recombination and Transposition

VIII OMICs 3h

24 Genomics

25 Proteomics

26 Transcriptomics

27 Metabolomics

IX RNA regulation 3h

28 small nuclear RNA (snRNP's)

29 SRP (signal recognition particle)

30 small nucleolar RNA (snoRNA) 

31 Micro RNAs [miRNA]

X Molecular Biology of Virus 3h

32 Classification

33 Gene, molecular mechanism of virus infection

34 Diagnosis and treatment, vaccine and vector

XI Discussions 2h

XII Examination 2h

III.Teaching Schedule:

Week

Course   Contents

Teaching Method

1

Introduction   (A Brief History, The Molecular Nature of Genes, An Introduction to Gene   Function, HGP)

Lecture

2

Methods   in Molecular Biology (Molecular Cloning Methods, Molecular Tools for Studying   Genes and Gene Activity)

Lecture

3

Transcription   in Prokaryotes (The Transcription Apparatus of Prokaryotes, Operons: Fine   Control of Prokaryotic Transcription, Major Shifts in Prokaryotic   Transcription, DNA-Protein Interactions in Prokaryotes)

Lecture

4

Transcription   in Eukaryotes (Eukaryotic RNA Polymerases and their Promoters, General   Transcription Factors in Eukaryotes, Transcription Activators in Eukaryotes,   Chromatin Structure and Its Effects on Transcription)

Lecture

5

Posttranscriptional   Events (Posttranscriptional Events I: Splicing, Posttranscriptional Events II:   Capping and Polyadenylation, Posttranscriptional Events III: Other Events)

Lecture

6

Translation   (The Mechanism of Translation I: Initiation, The Mechanism of Translation II:   Elongation and Termination, Ribosomes and Transfer RNA)

Lecture

7

DNA Replication,   Recombination, and Transposition (DNA Replication I: Basic Mechanism and   Enzymology, DNA Replication II: Detailed Mechanism, Homologous Recombination,   Site-Specific Recombination and Transposition)

Lecture

8

OMICs   (Genomics, Proteomics, Transcriptomics, Metabolomics, Informatics)

Lecture

9

RNA   regulation (small nuclear RNA, SRP, small nucleolar RNA, Micro RNAs)

Lecture

10


Lecture

11

Molecular   biology of virus (Classification, Gene, molecular mechanism of virus   infection, diagnosis and treatment, vaccine and vector)

Lecture

12


Lecture

13

Examination

Lecture

Note: 1.Above one, two, and three items are used as teaching Syllabus in Chinese and announced on the Chinese website of Graduate School. The four and five items are preserved in Graduate School.

2. Course terms: Spring, Autumn, and Spring-Autumn term. 

3. The teaching languages for courses: Chinese, English or Chinese-English.

4. Applicable range of discipline: public, first-class discipline, second-class discipline, and third-class discipline.

5. Practice includes: experiment, investigation, research report, etc.

6. Teaching methods: lecture, seminar, practice, etc.

7. Examination for degree courses must be in paper.

8. Teaching material websites are those which have already been announced.

9. Brief introduction of chief lecturer should include: personal information (date of birth, gender, degree achieved, professional title), research direction, teaching and research achievements. (within 100-500 words)